Natalia Grob, MD FACOG

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NATALIA M. GROB, M.D. 

EDUCATIONAL QUALIFICATIONS:

THREE-YEAR SUBSPECIALTY FELLOWSHIP IN REPRODUCTIVE

ENDOCRINOLOGYAND INFERTILTY

UNIVERSITY OF COLORADO DENVER

Denver, Colorado

COMPLETED FOUR-YEAR RESIDENCY IN OBSTETRICS AND GYNECOLOGY

WASHINGTON UNIVERSITY SCHOOL OF MEDICINE

St Louis, Missouri

M.D.

CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE

Cleveland, Ohio

B.A. IN BIOCHEMISTRY

SMITH COLLEGE

Northampton, Massachusetts

LICENSURE AND BOARD CERTIFICATION: 

Colorado State License 

Dual ABOG Board Certification in OBGYN & Reproductive Endocrinology & Infertility

HONORS AND AWARDS:

2017               Best Poster Presentation for Post-doctoral Fellows, Building Better Babies Research Symposium, University of Colorado, Denver, CO

2016               ASRM Corporate Member Council In-training Travel Grant

2015               Excellence in Resident and Medical Student Teaching

University of Colorado, Denver CO

2013               First Place-Acknowledgement of Excellence in Research

                        The 28^th Annual Dr. David Rothman Resident Research 

                        Washington University in St Louis

2013               First Place-President’s Gold Award for Scientific Research

                        St Louis OBGYN Society Annual Meeting

2010               Alpha Omega Alpha

                        Case Western Reserve School of Medicine

2010              The Harry Resnick Memorial Fund Award                      

                                                            Case Western Reserve School of Medicine                    

                                                            2007               NIH T35 Research Program Grant

                                                                                    Heart, Lung, Blood, and Sleep Program

                                                                                    Case Western Reserve School of Medicine

2006               Cum laude, Smith College

                                                            2006               Highest Honors in Biochemistry, Smith College

                                                            2006               Margaret Wemple Birgham Prize (Biology), Smith College

                                                            2005               Sigma Xi, Smith College

                                                            2005               Smith College Praxis Internship, Smith College

                                                            2005               Youth Service Organization Grant for Leadership 

Best Buddies Chapter, Smith College

                                                            2002-2006     STRIDE Scholar Research Grant, Smith College 

PROFESSIONAL SOCIETIES AND ORGANIZATIONS:

Section Editor, Current Obstetrics & Gynecology Reports: Environmental Exposures and Pregnancy Outcomes

Reviewer: Scientific Reports, JAMA, PlosOne

Pediatric Environmental Health Specialty Unit, West Program. Section VIII (Consultant)

Reproductive Environmental Health Assessment and Risk Reduction Guidance Expert Advisor Group. Agency for Toxic Substances and Disease Registry and American College of Medical Toxicology. (Advisory Group Member)

American College of Obstetricians and Gynecologists

                                    (Fellow)

                                                American Society for Reproductive Medicine 

                                                (Member)

                                                Alpha Omega Alpha

                                                (Member)

                                                Physician Mom Group (Member)

AWARDED GRANTS

2014                     Just in Time Grant. Washington University School of Medicine, St. Louis, Missouri. 

2015                     Academic Enrichment Fund. Department of Obstetrics & Gynecology. University of Colorado, Denver CO. 

2015                     Society for Reproductive Endocrinology and Infertility National Research Service Institutional Training Award (T32). 

MAJOR INVITED LECTURESHIPS:

October 10, 2018           Keynote spesaker: OBGYN screening for environmental exposures: A call for action. PEHSU regional conference in Chicago, IL.

June 16, 2018                Food for Life: How diet can influence fertility and pregnancy. American College of Obstetrics & Gynecology Colorado Symposium in Vail, CO. 

June 6, 2017                   Exposure to phthalate, an endocrine disrupting chemical, alters the first trimester placental methylome and transcriptome in women

March 22, 2017              OBGYN residents and faculty are least likely to screen for environmental exposures: results from OBGYN Screening for Environmental Exposures (OSEE). University of Colorado OBGYN Grand Rounds

October 17, 2016           Exposure to phthalate, an endocrine disrupting chemical, alters  first trimester placental gene expression in women. 71^st Annual Meeting of the American Society for Reproductive Medicine. Salt Lake City, Utah.

October 17, 2016           The effect of the endocrine disrupting chemical DEHP on the ovarian and adipose transciptome. 71^st Annual Meeting of the American Society for Reproductive Medicine. Salt Lake City, Utah.

April 19, 2013                 Endocrine disrupting chemicals impact ovarian function. Rothman Research Symposium. Washington University School of Medicine, St. Louis, Missouri.

April 10, 2013                 Endocrine disrupting chemicals impact ovarian function. St Louis OBGYN Society Annual Research Meeting. St. Louis, Missouri.

October 21, 2012           Endocrine disrupting chemicals impact ovarian function. 68^th Annual Meeting of the American Society for Reproductive Medicine. San Diego, California.

September 27, 2012      Endocrine disrupting chemicals impact ovarian function. Women’s Health Symposium. Washington University School of Medicine, St. Louis, Missouri.

BIBLIOGRAPHY:

Peer reviewed manuscripts:

1. Broughton D, Chen S, Crawford N, Feinberg E, Forman E, Grindler N, Kallen A, Kudesia R, Perfetto C, Shahine , Trolice M, Omurtag K.  Fertility and Sterility Dialog [Internet]. “Fertility Social Media Influencers, part 1: Your brand and your Narrative.  2019 September. Available from https://www.fertstertdialog.com/rooms/101-consider-this/posts/52945-omurtag-consider-this-part-1

• Broughton D, Chen S, Crawford N, Feinberg E, Forman E, Grindler N, Kallen A, Kudesia R, Perfetto C, Shahine , Trolice M, Omurtag K.  Fertility and Sterility Dialog [Internet]. “Rise of the social media influencer in fertility care, part 2: doin’ it (professionally) for the “Gram.” 2019 October. Available from https://www.fertstertdialog.com/users/16110-fertility-and-sterility/posts/54156-omurtag-consider-this-part-2

• Grindler, NM, L. Vanderlinden, R. Karthikraj, K. Kannan, S. Teal, A. J. Polotsky, T. L. Powell, I.V Yangand T. Jansson. Exposure to phthalate, an endocrine disrupting chemical, alters the first trimester placental methylome and transcriptome in women. Scientific Reports, 2018. 17;8(1):6086 

• Grindler NM, Allshouse AA, Jungheim E, Powell TL, Jansson T, and AJ Polotsky. OBGYN screening for environmental exposures: a call for action. Plos One, 2018. 16;13(5):e0195375

• Grindler N, Al-Safi Z, N Santoro. Menopausal Hormone Therapy. Comprehensive Toxicology. 3^rdEdition. 

• Grindler NM and N. Santoro. Exercise and Menopause. Menopause 2015. Dec;22(12):1351-8

• Grindler NM, Ng J, Tocce K, Alvero R. Considerations for management of interstitial ectopic pregnancies: case series. Journal of Medical Case Reports, accepted. 

• Reynolds KA, Grindler NM, Rhee JS, Cooper AR, Ratts VS, Jungheim ES. Variability in the practice of fertility preservation for patients with cancer. PlosOne 2015, 10(5):e0127335

• Grindler NM, Allworth JE, Macones GA, Roehl KA, Cooper AR. Do endocrine disrupting chemicals alter age of menopause? Evidence from the National Health and Nutrition Examination Survey, 1999-2008.PLoS ONE. 2015. 10(1): e0116057

1. Grindler NM, Moley KH. Maternal obesity, infertility, and mitochondrial dysfunction: potential mechanisms emerging from mouse model systems. Molecular Human Reproduction. 2013. 19(8): 486-494.

1. Jiminez PT, Frolova AI, Chi MM, Grindler NM, Willcockson AR, Moley KH. DHEA-mediated inhibition of the pentose phosphate pathway alters oocyte lipid metabolism in mice. Endocrinology. 2013. 154(12):4835-44.

1. Omurtag K, Grindler NM, Bates GW, Beltsos A, Odem R,  Jungheim ES. State-mandated insurance coverage is associated the approach to hydrosalpinges prior to IVF. Reproductive Biomedicine Online, 2014. 29(1):131-135 

1. Parker AK, Grindler N, Jungheim ES, Odem RR, Ratts VS, Cooper AR. Antral follicle count is increased in obese women placed on oral contraceptive pills. Journal of Reproductive Medicine 2015 60: 155-159

1. Omurtag K, Grindler NM, Roehl KA, Bates GW Jr, Beltsos AN, Odem RR, Jungheim ES. How members of the Society for Reproductive Endocrinology and Infertlity and Society of Reproductive Surgeons evaluate, define, and manage hydrsalpinges. Fertil Steril. 2012 May;97(5):1095-100.e1-2.

1. Luzzo KM, Wang Q, Purcell SH, Chi M, Jimenez PT, Grindler N, Schedl T, Moley KH. High fat diet induced developmental defects in the mouse: oocyte meiotic aneuoploidy and fetal growth retardation/brain defects. PLoS One. 2012;7(11):e49217.

1. , Cooper AR. Vulvovaginal and Mullerian Abnormalities. Nelson’s Textbook of Pediatrics: Chapter 548. 2013 Edition. 

1. , Aytekin M, Dweik RA. Biomarkers in exhaled breath condensate: a review of collection, processing and analysis. Journal of Breath Research 2008. 3(2): 18.

1. , Dweik RA. Exhaled nitric oxide: progress since the introduction of standardized methodology. Journal of Breath Research 2008. 2(3): 18.

• , Dweik RA. Exhaled nitric oxide in asthma. From diagnosis, to monitoring, to screening: are we there yet. Chest 2008. 133(4): 7. 

• , Laskowski D, Dweik RA. A technical report on exhaled nitric oxide measurement: asthma monitoring in athletes. Journal of Breath Research 2008. 2(3): 4.

Abstracts:

1. Grindler, NM, A. Allshouse, E. Jungheim,  A. J. Polotsky, T. L. Powell, T. Jansson , and N. Santoro. OBGYN physician screening for environmental exposures (OSEE): a call for action. Annual Meeting of the American Society for Reproductive Medicine, submitted.

• Grindler NM, Yang K, Vanderlinden L, Rajendiran K, Kannan K, Polotsky AJ, Teal S,  Schwartz D, Powell T, Jansson T. Phthalate exposure alters first trimester placental gene methylation in women. Pacific Coast Reproductive Society, accepted as oral presentation.

• Grindler NM, Yang K, Vanderlinden L, Rajendiran K, Kannan K, Polotsky AJ, Teal S,  Schwartz D, Powell T, Jansson T. Phthalate exposure alters first trimester placental gene methylation in women. Society for Reproductive Investigation, accepted as poster presentation.

• Grindler NM, Yang K, Rajendiran K, Kannan K, Polotsky AJ, Teal S,  Schwartz D, Powell T, Jansson T. Exposure to phthalate, an endocrine disrupting chemical, alters first trimester placental gene expression in women. Midwest Reproductive Symposium, accepted as poster presentation. 

• Grindler NM, Yang K, Rajendiran K, Kannan K, Polotsky AJ, Schwartz D, Powell T, Jansson T. The effect of the endocrine disrupting chemical DEHP on the ovarian and adipose transcriptome. Annual Meeting of the American Society for Reproductive Medicine, accepted as oral presentation. 

• Grindler NM, Yang K, Rajendiran K, Kannan K, Polotsky AJ, Teal S,  Schwartz D, Powell T, Jansson T. Exposure to phthalate, an endocrine disrupting chemical, alters first trimester placental gene expression in women. Annual Meeting of the American Society for Reproductive Medicine, accepted as oral presentation. 

• Grindler NM, Crowley J, Giblin D, Rohrs H, Cooper AR. Do endocrine disrupting chemicals pose a transgenerational health risk? A pilot study evaluating the transmission of polychlorinated biphenyls from mom to baby. 70^th Annual Meeting of the American Society for Reproductive Medicine, submitted.

• Tsai S, Grindler NM, Beaver, E, Longman R, Cooper AR. Cell free fetal DNA (cffDNA) testing and infertility patients: will discordant gender results be more common than previously expected? A plea for caution and research. 70^th Annual Meeting of the American Society for Reproductive Medicine, submitted.

• Grindler NM, Delli-Zotti K, Allworth J, Cooper AR. Endocrine disrupting chemicals impact ovarian function and ovarian reserve. Rothman Research Day 2013. St Louis, MO.

1. Grindler NM, Jimenez PJ, Willcockson AR, Chi MM, Moley KH. Dehydroepiandrsterone alters lipid metabolism in the oocyte via the pentose phosphate pathway. 60th Annual Meeting of the Society for Gynecologic Investigation. (Abstract #F-202) Orlando, Florida.

1. Reynolds K, Grindler NM, Cooper AR, Ratts V, Jungheim ES. The practice of fertility preservation: a national provider survey. 60th Annual Meeting of the Society for Gynecologic Investigation. (Abstract #S-037) Orlando, Florida.

1. Grindler NM, Delli-Zotti K, Allworth J, Cooper AR. Endocrine disrupting chemicals impact ovarian function and ovarian reserve. 68th Annual Meeting of the American Society for Reproductive Medicine. (Abstract #O-101) San Diego, California.

1. Omurtag K, Grindler NM, Bates GW, Beltsos A, Odem R, Jungheim, ES. State-mandated insurance coverage impacts the approach to hydrosalpinges prior to IVF. 68th Annual Meeting of the American Society for Reproductive Medicine. (Abstract #P-390) San Diego, California.

1. Parker AK, Grindler N, Jungeheim ES, Odom RR, Ratts VS, Cooper AR. BMI influences the impact of oral contraceptive pills and GnRH agonists on antral follicle count ovarian reserve screens. 67^th Annual Meeting of the American Society for Reproductive Medicine.  (Abstract #P-311)  Orlando, Florida. 

1. Grob NM, Dweik RA. Exhaled nitric oxide and asthma- what can FENO really tell us? Lepow Research Day, Case Western Reserve University. Cleveland, Ohio (2009).

1. Grob NM, Dweik RA. Exhaled nitric oxide and asthma- what can FENO really tell us? Poster presented at Lerner Research Institute Pathobiology Department. Cleveland, Ohio. (2009).

1.  Grob NM, Li W, Williams SA. Use of microarrays to evaluate the gene expression in the L3 and L4 stage of the filarial parasite Brugia malayi. Oral Presentation at The American Society of Tropical Medicine & Hygiene Annual Conference. Atlanta, Georgia (2006).

1.  Grob NM, Williams SA. Use of microarrays to evaluate the gene expression in the L3 and L4 stage of the filarial parasite Brugia malayi. Oral Presentation presented at: Smith College Annual Thesis Presentation- Biochemistry Department.  Northampton, MA. (2006). 

1. Grob NM, Mikic B. GDF-7 in bone growth and ligament repair. Poster presented at Smith College STRIDE Research Meeting. Northampton, Massachusetts (2003).